Biden was speaking in a CBS News interview aired on Sunday, the BBC reported.
However, Iran’s Supreme Leader, Ayatollah Ali Khamenei, said Tehran would only return to compliance if the US first lifted all economic sanctions.
The 2015 deal sought to limit Iran’s nuclear programme, with sanctions eased in return.
Former US President Donald Trump, however, withdrew the US from the deal in 2018 and re-imposed sanctions, leading Iran to roll back on a number of its commitments.
Iran, which says its nuclear programme is peaceful, has been increasing its stockpile of enriched uranium. Enriched uranium can be used to make reactor fuel, but also nuclear bombs.
Under the terms of the 2015 nuclear deal – an agreement reached between Iran, the US, China, France, Germany, Russia and the UK – Tehran agreed to limit its uranium enrichment and allow international inspectors to access sites and facilities.
In return, sanctions imposed on Tehran were lifted.
But Trump withdrew the US from the deal, known as the Joint Comprehensive Plan of Action (JCPOA), in an effort to force Iran to negotiate a new accord, and reinstated economic sanctions.
Trump wanted to place indefinite curbs on Tehran’s nuclear programme and also halt its development of ballistic missiles.
Ali Khamenei said that for Iran to return to its commitments under the deal, the US must first “abolish all sanctions”, Iranian state TV reported on Sunday.
“We will assess, and if we see that they have acted faithfully in this regard, we will return to our commitment,” he said, adding: “It is the irreversible and final decision and all Iranian officials have consensus over it.”
The president also talked about the US relationship with China.
He said there was no reason for Washington to be drawn into direct conflict with Beijing, but that both sides would engage in what he called “extreme competition” on the global economic stage.
Biden said he had not spoken to his Chinese counterpart, Xi Jinping, since becoming president last month, and that he had not changed his stance towards Beijing.
“He’s very bright, he’s very tough,” Biden said of Xi, adding: “He doesn’t have a democratic – small ‘d’ – bone in his body.”
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